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During the transmission phase, the signals from the nociceptors are transmitted to the spinal cord and then to the brain. This phase occurs within 100-500 milliseconds of the initial painful stimulus. The signals are transmitted through specialized nerve fibers, including A-delta and C-fibers.

You might notice a few interruptions during this arc. Specifically:

During the modulation phase, the brain responds to the pain by releasing various neurotransmitters and hormones that can either enhance or inhibit the pain signal. This phase occurs within 1000-2000 milliseconds of the initial painful stimulus. The brain can also draw on past experiences and emotional state to influence the perception of pain.