Amisha Patel is also known for her philanthropic work, particularly in the area of education and healthcare. She has supported several charitable organizations, including the American Cancer Society and the Akshaya Patra Foundation. In 2011, she was appointed as a Goodwill Ambassador for the United Nations Population Fund.

Amisha Patel is married to Rajesh Handa, a businessman, and the couple has a daughter, Naisha, born in 2008. Despite being a celebrity, Amisha prefers to keep her personal life private and away from the spotlight.