If your goal is portfolio management, Coinigy offers a web-based platform that feels like a desktop app. Delta and Blockfolio (now FTX) have traditionally been mobile-first but are increasingly supporting desktop interfaces.
For serious enthusiasts, Windows 10 is the OS of choice for hardware wallets and mining rigs. A tool like BitVision would ideally bridge the gap between the blockchain and the hardware, offering a visual interface for local nodes or wallet status. bitvision for pc windows 10